Breaking news ! Vitamin C works to prevent SARS-CoV-2 infection

Vitamin D also works. Shocker !

This is a more light one, for the fun of it. This isn’t exactly news, anyone with a functional brain knew this back in early 2020, but the propaganda machine and lack of common worked hard to make most of the planet believe otherwise.

It is good to finally have some form of scientific evidence demonstrating the obvious (to us).

Vitamin C is an efficient natural product for prevention of SARS-CoV-2 infection by targeting ACE 2 in both cell and in vivo mouse models

Ok, while the title is rather simple, the science speak is rather difficult for the average person. And some of these concepts are vital for both life and understanding much of the aspects some people push and I call BS (amyloid). I will make it extremely simplistic, so don’t hold it too high.

First, Ubiquitin is a small protein that works as, in a very simplistic way, a tag system. Ubiquitination is the process of “tagging” different other proteins, among other effects, to degradation. A bad protein would be “tagged” by this, and marked to get recycled, “eaten up” by your body.

USP50 is a gene that directly controls ACE2 stability and levels, and it is a deubiquitinase, meaning it does the opposite, it can market certain proteins to NOT be degraded. Blocking the interaction means ACE2 will be degraded.

Not only this, Vitamin C itself regulates the ACE2 levels.

A very nice representation of what was discussed here.

The authors go on to describe their thought process, design methods, and findings, which in the end is pretty clear.

Thus, this study provided evidence that VitC could be not good for the therapy of COVID-19 at the late stage of SARS-CoV-2 infection, which many clinical therapeutic studies actually have been performing for COVID-19, since VitC dramatically reduces ACE2 levels. Here, our study suggested that VitC administration is an efficient strategy for daily protection from SARS-CoV-2 infection, and also possibly for the therapy of early SARS-CoV-2 infection.

Now, there are a few strategies to achieve decent concentrations of Vitamin C around your body, per the authors themselves note, tissue levels and plasma (blood) levels differ greatly, tissue can store more than plasma. So here is what you can/should do.

• If you are using cheap, common Vitamin C (I use effervescent tablets), you should break the equivalent of 500 mg (in my case, 4 pieces) and take 1 piece every 3 to 4 hours. Clarification. You should take 500 mg every 3 to 4 hours, making a total of 2000 mg/daily. No side-effects doing this dosage regimen too.

• If you can afford/want, Liposomal C will get you into higher levels quicker, but still, the pharmacokinetics of Vitamin C is weird, and there is still a threshold, you might still piss some of that C off.

• If you can afford it, and this was introduced to me by someone I respect a lot, C-Salts. Their formulation and chemical structure are different, and you can get the same dosages the paper notes from IV, with C Salts.

• Last resort, IV.
  

C is cheap enough anywhere that with some minor adjustments, anyone can use this for daily protection, and it works for a lot of other things. For the record I never used C-Salts (absurdly expensive here), but have heard amazing things from a lot of people, it is a good thing to have. Pay extra attention to HOW you store it, humidity can get in and ruin it pretty easily if you are not taking it daily.

Also as a last fun poke at “The Science” and parts of the quasi-religious vaccine believers.

Effect of Vitamin D3 supplementation vs. dietary-hygienic measures on SARS-COV-2 infection rates in hospital workers with 25-hydroxyvitamin D3 [25(OH)D3] levels >20 ng/mL

Results

We analyzed 198 participants, with an average age of 44.4 (SD 9) years, and 130 (65.7%) were women. G1 had less cases of SARS-COV-2 infection than G2 after a follow-up of 3- to 6-months (p<0.05). There were no differences between G3 and G4 at the 3- and 6-month follow-up cutoff points (p>0.05). Using mixed effect Cox regression analysis in 164 participants that completed six months of follow-up, vitamin D3 supplementation appeared to act as a protective factor against SARS-COV-2 infection (HR 0.21, p=0.008) in G1 and G2. None of the participants treated with the supplementation doses had serum 25(OH)D3 levels > 100ng/mL.

Conclusion

Vitamin D3 supplementation in participants with 25(OH)D3 levels between 20-100 ng/mL have a lower rate of SARS-COV-2 infection in comparison with the use of dietary-hygienic measures at six months follow-up.

Vitamin D also works. Shocking.

The obvious, we finally have it.

A very big thank you to all supporters here and those who use KoFi =) !