Bio briefings are always mixed, remember that =).
So, in the morning, a post from a new account went viral, at an alarming speed, I screen capped it.
There is a fairly old news, that keeps coming back, about the permafrost melting and a “lethal” virus leaking out and infecting people. Using that news as a backbone meme, someone (FSB most likely) tried to stress test the response of social media, using another news as a sort of digital catapult.
This is merely one of the many “stress tests” you can track down in social media, if you know how to look for it. Later in the day the one below made the rounds in specific Twitter circles.
Rare hemorrhagic fever found in Britain for the first time in more than a decade
Health authorities said they have diagnosed two cases of a viral hemorrhagic fever in Britain, and possibly a third -- marking the first time the illness has been seen in the country in over a decade.
Officials said the cases of Lassa fever involve members of the same family and are linked to recent travel to western Africa, where the illness is endemic. Two of the cases are conclusive and the third hasn't been confirmed yet.
Most people on social media, specially grifter types, or people seeking attention, and other types of actors often don’t read, or ignore the entire article. As you can see, the article itself mentions Africa, but here, the source of it.
Nigeria reports nearly 100 confirmed Lassa fever cases in first two weeks of 2022
For the second week in a row, Nigerian health officials reported 48 confirmed Lassa fever cases in the country, bringing to total confirmed cases to 96 through January 16.
As Africa enter a state of Forever War, constant collapse and a battlefield for international (Western x Chinese and Russian interests), and infrastructure can’t keep up with the damage of the Nova Swan, old and new plagues alike will surface. And Africa will become a vector for disease to Europe.
This isn’t me talking, this is the UN book about defense against the age of bioterrorism.
And a news that is more personal than anything else. Check this (shitposting, a thread made mostly for fun).
A big discussion between researcher specialized in Ebola virus, is latency/persistence. And here we are.
Ebola virus persistence and disease recrudescence in the brains of antibody-treated nonhuman primate survivors
In new work, Liu et al. report frequent EBOV persistence in the brain ventricular system of nonhuman primates that survived acute disease after monoclonal antibody–based treatment. Viral persistence was associated with lethal recrudescence of disease including severe inflammation in the brain. These findings have implications for long-term follow-up efforts to reduce the individual (disease relapse/recrudescence) and public health (reignition of outbreaks) consequences of viral persistence in survivors of EBOV infection.
This has severe implications, not only for policy, borders and epidemic control, but it has an extensive importance for bioterrorism. I will explain.
A non-state actor creates a variant that can infect, and lay dormant for weeks, and then becomes fatal. Feels far-fetched, right ? But all fields related to viruses, infections and anything in between advanced so much in the last 2 years alone…
If you are asking yourself why would Pfizer do it, it’s not by social media pressure, or anything else, but not being able to fudge the data to get approval, even if the FDA is corrupt and almost useless, even then couldn’t turn a blind eye to this.
I said a few times to some people, kids react way faster to the side effects. It’s pretty easy to track it too, you can track on social media the last 4 months. The younger the vaccinated are, the faster their reaction speed is, specially in people younger than 40.
FDA will also be releasing all the documents the vaccine manufactures wanted to keep sealed for decades, which is another reason Pfizer is pulling out. The data, after properly examined, will be overwhelmeing bad, with enough safety signals to raise alarm bells every 2 or 3 pages.
For the entire week, people kept asking me about this article and ones alike.
Highly virulent HIV variant found circulating in Europe
The mutated strain’s effects are more severe, and it is more transmissible — but drugs are still effective against it.
The findings, published in Science on 3 February1, serve as a reminder that viruses do not always evolve to become less virulent over time. Reports that infections with the Omicron variant of SARS-CoV-2 tend to cause mild COVID-19 symptoms have fuelled the narrative that the virus is becoming less deadly. “This is not how it works,” says Emma Hodcroft, a molecular epidemiologist at the University of Bern. Although HIV and SARS-CoV-2 are different in many ways, “it’s not a given that SARS-CoV-2 will become milder”, Hodcroft says.
Compared with people infected with other HIV strains, those infected with the new variant had up to 5.5 times more virus in their blood, and their CD4 T cells dwindled nearly twice as fast. A drop in CD4 T cells, which help to coordinate the body’s immune response to infections, is a tell-tale sign that HIV has damaged the immune system.
From the paper mentioned in the article above.
More than one hundred individuals infected with a characteristic subtype B lineage of HIV-1 were found who experienced double the rate of CD4+ cell count declines than expected. By the time they were diagnosed, these individuals were vulnerable to developing AIDS within 2 to 3 years. This virus lineage, which has apparently arisen de novo since around the millennium, shows extensive change across the genome affecting almost 300 amino acids, which makes it hard to discern the mechanism for elevated virulence. —CA
Both texts are self-explanatory, it’s something most reader should get used to, since tracking has become fairly cheaper given the SARS-CoV-2 pandemic, researchers will start to find new, more pathogenic variants, of certain viruses sometimes. It’s a good example going against the narrative of viruses always evolve to spread. They can evolve to do both things, and science has many examples.
And suddenly, AIDS was all the talk in town the last couple of days, thanks to this paper. Anything outside quotes (big bar on the left side of text) is me interjecting.
SARS-CoV-2 Uses CD4 to Infect T Helper Lymphocytes
Here we show that SARS-CoV-2 infects human CD4 + T helper cells, but not CD8 + T cells, and is present in blood and bronchoalveolar lavage T helper cells of severe COVID-19 patients. We demonstrated that SARS-CoV-2 spike glycoprotein (S) directly binds to the CD4 molecule, which in turn mediates the entry of SARS- CoV-2 in T helper cells in a mechanism that also requires ACE2 and TMPRSS2. Once inside T helper cells, SARS-CoV-2 assembles viral factories, impairs cell function and may cause cell death. SARS-CoV-2 infected T helper cells express higher amounts of IL-10, which is associated with viral persistence and disease severity. Thus, CD4-mediated SARS-CoV-2 infection of T helper cells may explain the poor adaptive immune response of many COVID-19 patients
“individuals that progress to the severe stages of COVID-19 manifest marked
alterations in the immune response characterized by reduced overall protein synthesis, cytokine storm, lymphocytopenia and T cell exhaustion 6-8 . In addition to these acute effects on the immune system, most convalescent individuals present low titres of neutralizing antibodies. Moreover, the levels of antibodies against SARS-CoV-2 decay rapidly afte recovery, suggesting that SARS-CoV-2 infection may exert profound and long-lasting complications to adaptive immunity.”
A lot to unpack here. Authors demonstrate that the S (spike) protein from the vrus can directly bind to CD4 cells, which in turn can use the cells as a replication factory, and causing death (that can lead to a transient state of immune suppression). Like with any type of immune response, too much of anything, is bad. Too much of IL-10 will immune suppress you.
IL-10 is a powerful anti-inflammatory cytokine and has been previously associated with viral persistence.
Consistent with these findings, we found that expression of IL10 positively correlates with viral load in CD4 + T cells. This is an unique feature of patients with the severe form of COVID-19, since we could not detect the virus in CD4 + T cells from patients with the moderate form of the disease and IL10 expression in CD4 + T cells is much lower in these patients. In contrast, we found IFNG and IL17A to be upregulated in CD4 + T cells of patients with the moderate illness, indicating a protective role for these cytokines. However, in patients with the severe symptoms, the expression of IFNG and IL17A in CD4 + T cells is dampened. IL-10 is a known suppressor of Th1 and Th17 esponses and it is likely to contribute to the changes in IFNG and IL17A. These features will ultimately reflect in the quality of the immune response, which in combination with T cell death and consequent lymphopenia, may result in transient/acute immunodeficiency and impair adaptive immunity in severe COVID-19 patients.
Source.
“Our results suggest that in some patients the novel coronavirus can cause acute immunodeficiency not only by killing some of the subject’s CD4+ T lymphocytes but also by impairing their function. The outcome is that the CD8+ T lymphocytes proliferate less and the B lymphocytes produce antibodies with less affinity and duration. The effect is similar to that of HIV but acute,” Alessandro Farias, co-principal investigator for the study, told Agência FAPESP.
This mechanism is entirely different (reverse literally) from where I am going with my virus posts, but in this case, it’s mostly in severe patients. And my focus is the immune dysfunction set off by the jab and how it fuels and set off diseases. Nevertheless, it’s a pertinent paper, and in my opinion, it’s a response to the immune shift and skew the infection causes between moderate to severe cases, which usually go down really fast.
As a way to protect the entire body and organs, the body responds with a overwhelming immuno suppressive response, which aides virus persistence inside your body (very important later on). Less CD8 as a byproduct of CD4 dysfunction and death leads to similar outcomes as the jab. Without CD8 your body can’t fight chronic or secondary infections.
Viral reactivation. Which now is being explored as one of the possible causes in a portion of the Long Covid patients.
As of note, I see some chatter between grifters are starting to jump in the AIDS train. Here.
GP120 has multiple functions in my opinion, one of the main ones is that it acts as a molecular clamp.
And for last, this interesting pre-print.
You do well do read the part about non-neutralizing antibodies in the A Casa For Reverse Marek. Not only the vaccine produces tons of (non-neutralizing) antibodies, they are of lower quality than natural infection. If you read most of my virus posts you can quite well tell why, and why this is a major problem.
No new posts for Sunday, taking the day out, only if something really important goes down. Still have 3 days and 20 hours of Twitter jail. I will work on Reverse AIDS Part IV in the mean time. It will be quite a big one, and the most important one so far.