A stronger case for Reverse Marek

Maybe CD8 were important after all...

Non-virus post coming soon, this is one more of me smirking at the camera one.

You should read the one below, and It’s (viral) Evolution baby first.

The case for Reverse Marek's

After trying to mess with the data, hide, and do whatever it takes to keep Pfizer stocks high, the truth is getting out of Israel. The reader will do well to remember, that Israel is usually 3 to 4 months ahead of most of the world in terms of what happens when it comes to SARS-CoV-2.

My case for a Reverse Marek scenario makes itself stronger, and it will keep doing it for the weeks ahead, globally.

And this article.

Obviously, this isn’t the first case, and there is literature on this, and especially on ADE.

Vaccine-induced enhancement of viral infections

Examples of vaccine-induced enhancement of susceptibility to virus infection or of aberrant viral pathogenesis have been documented for infections by members of different virus families. Several mechanisms, many of which still are poorly understood, are at the basis of this phenomenon. Vaccine development for lentivirus infections in general, and for HIV/AIDS in particular, has been little successful. Certain experimental lentiviral vaccines even proved to be counterproductive: they rendered vaccinated subjects more susceptible to infection rather than protecting them. For vaccine-induced enhanced susceptibility to infection with certain viruses like feline coronavirus, Dengue virus, and feline immunodeficiency virus, it has been shown that antibody-dependent enhancement (ADE) plays an important role. Other mechanisms may, either in the absence of or in combination with ADE, be involved. Consequently, vaccine-induced enhancement has been a major stumble block in the development of certain flavi-, corona-, paramyxo-, and lentivirus vaccines. Also recent failures in the development of a vaccine against HIV may at least in part be attributed to induction of enhanced susceptibility to infection. There may well be a delicate balance between the induction of protective immunity on the one hand and the induction of enhanced susceptibility on the other.

In the post Reverse AIDS hypothesis I make the case that, the virus to a minor degree, the vaccine to a systemic one, is immuno suppressing people. In Substack itself and on Twitter you can find many writers using quite a few scientific papers showing that the vaccinated never create antibodies to the N protein, a very important part of the virus, not the most toxic (that would be the S, spike protein) but important for broad immunity.

The paper below will make my argument for itself. A reminder for the laypeople or if you didn’t read the Reverse AIDS hypothesis anyway, the mRNA vaccine has ZERO CD8 response for MONTHS. And even after infection, the vaccinated doesn’t create N antibodies.

Strong SARS-CoV-2 N-specific CD8+ T immunity induced by engineered extracellular vesicles associates with protection from lethal infection in mice

SARS-CoV-2-specific CD8+ T cell immunity is expected to counteract viral variants in both efficient and durable ways.

When immunized mice were infected with 4.4 lethal doses 50% of SARS-CoV-2, all S1-immunized mice succumbed, whereas those developing the highest percentages of N-specific CD8+ T lymphocytes resisted the lethal challenge. We also provide evidence that the N-specific immunization coupled with the development of antigen-specific CD8+ T-resident memory cells in lungs, supporting the idea that the Nefmut- based immunization can confer a long-lasting, lung-specific immune memory. In view of the limitations of current anti-SARS-CoV-2 vaccines in terms of antibody waning and efficiency against variants, our CD8+ T cell-based platform could be considered for a new combination prophylactic strategy.

Broad and strong memory CD4+ and CD8+ T cells induced by SARS-CoV-2 in UK convalescent individuals following COVID-19

In mild cases, higher proportions of SARS-CoV-2-specific CD8+ T cells were observed.

Impaired Cytotoxic CD8 + T Cell Response in Elderly COVID-19 Patients

SARS-CoV-2 infection induced a vigorous cytotoxic CD8+ T cell response. However, this cytotoxic profile of T cells was not detected in COVID-19 patients over the age of 80 years. Thus, the absence of a cytotoxic response in elderly patients might be a possible reason for the more frequent severity of COVID-19 in this age group than in younger patients.

My case for a Reverse Marek scenario remains strong, not only do the vaccinated doesn’t generate antibodies to a very significant part of the virus, they have no CD8, and they can’t clear the virus that well (they will have pieces of S1 protein floating around for months), among other nasty aspects of this.

You are going to see me ask this to the reader a few times in the next parts of any post about SARS-CoV-2.

Do you still think breakthrough infections are harmless ?

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